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Neural tube defects and folic acid

Folic Acid & Neural Tube Defects: Overview CD

Folic acid is a B vitamin. If a woman has enough folic acid in her body before and during early pregnancy, it can help prevent neural tube defects. Women need 400 micrograms (mcg) of folic acid every day. Women can get folic acid by Folic acid is the only type of folate shown to help prevent neural tube defects (severe birth defects of the brain or spine). 1-4 6 No scientific studies exist that show that supplements containing other types of folate (such as 5-MTHF) can help prevent neural tube defects The trials using folic acid to prevent neural tube defects thus seem to be effectively overcoming a metabolic block rather than treating folate deficiency Increasing folic acid intake among women of childbearing age can help prevent 150,000-210,000 of the more than 300,000 neural tube defects that occur each year in low- and middle-resource countries (5)

Neural Tube Defects (NTD): Folic Acid and Pregnancy. TIn the US, one in 1000 births is affected by neural tube defects (NTD). A neural tube defect is a birth defect involving the malformation of body features associated with the brain and spinal cord. An NTD originates from and is characterized by incomplete closure of the neural tube, which is. Neural tube defect and folic acid. Wani MA. PIP: Neural tube defect (NTD) is a group of congenital anomalies, which include anencephaly, encephalocele, iniencephaly, meningocele, myelomeningocele, myeloschisis, lipomeningocele, and rashischisis. Congenital malformations of the central nervous system constitute more than half of all congenital. 1. Indian Pediatr. 2004 Jun;41(6):577-86. Neural tube defects and folic acid. Gupta H(1), Gupta P. Author information: (1)Department of Pediatrics, University College of Medical Sciences, Delhi 110 095, India. PMID: 15235163 [Indexed for MEDLINE 1. Duodecim. 1996;112(11):975-82. [Neural tube defects and folic acid]. [Article in Finnish] Ritvanen A(1). Author information: (1)Family Federation of Finland, Helsinki. PMID: 1059299

Neural tube defects (NTDs), characterized by a failure of the neural tube to close properly after conception, affect about one per 1,000 livebirths in the United States (1). Observational and experimental studies have shown that periconceptional folic acid supplementation can significantly reduce the risk of NTDs (2, 3) Observational studies done before fortification report a reduction of neural tube defects in women taking a supplement with 0.4 mg (400 mcg) of folic acid (the generally available dose). Evidence.. Neural tube defect surveillance and folic acid intervention--Texas-Mexico border, 1993-1998. Centers for Disease Control and Prevention (CDC). Neural tube defects (NTDs) are common and serious malformations that originate early in pregnancy Neural tube defects are serious birth defects of the brain and spine. They develop very early in pregnancy when the neural tube, which becomes the brain and the spine, does not close properly. Folic acid is needed for the neural tube to close properly Management issues for women with epilepsy: neural tube defects and folic acid supplementation Neurology. 2003 Sep 1;61(6 Suppl 2):S23-6. doi: 10.1212/wnl.61.6_suppl_2.s23. Author Mark S Yerby 1 Affiliation 1 Department of Obstetrics and.

MTHFR Gene, Folic Acid, and Preventing Neural Tube Defects

CDC's Morbidity and Mortality Weekly Report published a new study looking at how many serious birth defects of the brain and spine, called neural tube defects (NTDs), have been prevented since the U.S. Food and Drug Administration required that all enriched grain products be fortified with folic acid Mediterranean diet, folic acid, and neural tube defects Ital J Pediatr. 2017 Aug 17;43(1):74. doi: 10.1186/s13052-017-0391-7. Authors Maximilian Fischer 1 , Mauro Stronati 2 , Marcello Lanari 3 Affiliations 1 Department of Pediatric Emergency, S. Orsola-Malpighi Hospital. A protective effect of folate against the development of neural tube defects (NTDs), specifically, anencephaly and spina bifida, is now well recognized, having been established by a chain of clinical research studies over the past half century

Folic acid metabolism and mechanisms of neural tube defect

Abstract: Neural tube defects (NTDs) are common complex congenital malformations resulting from failure of the neural tube closure during embryogenesis. It is established that folic acid supplementation decreases the prevalence of NTDs, which has led to national public health policies regarding folic acid. To date, animal studies have not provide With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between 1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk. Therefore, folic acid supplementation should be started 5-6 months before conception. The residual risk with optimal red-blood-ce Dietary supplementation with folic acid around the time of conception has long been known to reduce the risk of neural tube defects (NTDs) in the offspring.1-4This article reviews the metabolism of folic acid, the appropriate use of folic acid supplementation in pregnancy, and the potential benefits of folic acid, as well as the possible supplementation of l-methylfolate for the prevention of pregnancy-related complications other than NTD A new study suggests there might be a link between the Down syndrome and neural tube defects, and folic acid supplements may be an effective way to prevent both. Neural tube defects are caused by.. HealthLinkBC File #38c provides information on folate and neural tube defects including what folate and folic acid are, why folate is important during pregnancy, what and how common neural tube defects are, what increases risk of a baby with neural tube defect, how much folate is recommended, how to get more folate and folic acid from your diet, good food sources of folate, and where to find.

One prospective (but nonrandomized) cohort study has been described. Milunsky et al assessed dietary folate plus a folic acid-containing multivitamin begun ≥1 mo before conception and continued through the first trimester.There were 10 NTD pregnancies among 10 713 women who took folic acid compared with 39 among 11 944 women who took multivitamins without folic acid, a relative risk of 0. 3. Folate status, folic acid supplementation and neural tube defect 3.1 Since 1964, it has been recognised that her folate status might affect a woman's risk of having a baby with an NTD . The evidence was, however, non specific and inconclusive. Women with affected pregnancies had significantly lower red cell folate levels tha

Folic Acid & Neural Tube Defects: Data & Statistics CD

Folic acid and neural tube defects Folic acid, or folate, is one of the B vitamins important for the healthy growth of your unborn baby. It helps reduce the risk of your baby being born with neural tube defects (NTDs) Millones de Productos que Comprar! Envío Gratis en Productos Participantes Berry RJ, Li Z, Erickson JD, Li S, Moore CA, Wang H, Mulinare J, Zhao P, Wong LY, Gindler J, Hong SX, Correa A: Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med. 1999, 341: 1485-1490. 10.1056/NEJM199911113412001 10. Wald NJ. Folic acid and the prevention of neural tube defects. N Engl J Med 2004;350:101-3. 11. Wald NJ, Law MR, Morris JK, et al. Quantifying the effect of folic acid. Lancet 2001;358:2069-73. 12. National Survey of Pakistan 1990-94. Islamabad: PMRC, 1998. 13. Berry RJ, Zhu LI, Ericson DJ, et al. Prevention of neural tube defects with. BACKGROUND: It is well established that women who have had a pregnancy affected by a neural tube defect (NTD) have an elevated risk of a subsequent NTD-affected pregnancy and that a high dose (4 mg/day) of folic acid taken around the time of conception prevents most recurrences of NTDs

Although all women of childbearing age are at risk of having a pregnancy affected by neural tube defects and should take folic acid supplementation, some factors increase their risk, including a. The USPSTF did not review the evidence on folic acid food fortification, counseling to increase dietary intake, or screening for neural tube defects. Recommendation: The USPSTF recommends that all women planning or capable of pregnancy take a daily supplement containing 0.4 to 0.8 mg (400 to 800 µg) of folic acid. (Grade A recommendation) Neural tube defects are associated with numerous factors that could be either genetic or environmental, 11 but folic acid deficiency is the predominant preventable contributor of NTDs. 12,13 The universal supplementation of folic acid is expected to decrease the incidence of NTDs; however, folate non-responsive NTDs continue to occur.

Folate and its cousin folic acid are vital for developing a healthy baby because it prevents neural tube defects. Since the neural tube develops within the first 28 days of pregnancy, it is recommended all women of childbearing years consume folate. Folate prevents certain heart abnormalities, cleft palate and cleft lip Prevention in pregnancy. Pregnant women or women who wish to become pregnant should be advised to take supplementation with folic acid before conception and until week 12 of pregnancy.. A higher daily dose (see folic acid) is recommended for women at a high risk of conceiving a child with a neural tube defect, including women who have previously had an infant with a neural tube defect, who are. The American Academy of Pediatrics endorses the US Public Health Service (USPHS) recommendation that all women capable of becoming pregnant consume 400 μg of folic acid daily to prevent neural tube defects (NTDs). Studies have demonstrated that periconceptional folic acid supplementation can prevent 50% or more of NTDs such as spina bifida and anencephaly KEY WORDS Folate, folic acid, neural tube defect, spina bifida, anencephaly, congenital malformations, birth defects INTRODUCTION A relation between folate and neural tube defects (NTDs), first suggested a little ! 50 y ago (1), has become recognized as a result of a large number of clinical investigations. Research i Folic acid is a B vitamin that dramatically reduces the risk of one of the most serious and potentially preventable birth defects called neural tube defects (NTDs). At least 3,000 pregnancies per year (more than 8 families per day) and 2,500 live births in the United States are affected by NTDs1. In 1992, the Unite

community on the importance of taking folic acid supplements in the periconceptional period. Prevention of neural tube defects All women, from the moment they begin trying to conceive until 12 weeks of gestation, should take a folic acid supplement. Women wh The authors reported a protective effect of folic acid against neural tube defects: 1 neural tube defect occurred in 3056 women who took folic acid supplements and 9 occurred in 3056 women who did not. The difference between the supplemented and unsupplemented groups was statistically significant after adjustment for birth order, chronic. 3. Folate status, folic acid supplementation and neural tube defect 3.1 Since 1964, it has been recognised that her folate status might affect a woman's risk of having a baby with an NTD . The evidence was, however, non specific and inconclusive. Women with affected pregnancies had significantly lower red cell folate levels tha Since 1998, enriched cereal grains sold in the United States have been fortified with folic acid, to reduce the incidence of neural tube defects (NTDs). The Centers for Disease Control and Prevention (CDC) recently reported that NTD rates have decreased 26% since fortification, but that additional effort is needed to achieve the national goal. The aim of this review paper is to demonstrate the breakthrough in the primary prevention of neural-tube defects (NTD) and the possible reduction of congenital heart defects by employing folic acid (FA)-containing multivitamin or folic acid during the periconception period, and to present their three applications in medical practice

To make sure you have enough folic acid in your body to prevent neural tube defects, the CDC recommends women who plan to become pregnant or who are of childbearing age take 400 mcg of folic acid. The benefit of folic acid supplementation during the periconception period in reducing the risk of neural-tube defects in offspring has been demonstrated both in experimental and in observational. Periconceptional folic acid significantly reduces the risk of neural tube defects. It is difficult to achieve optimal levels of folate by diet alone, even with fortification of flour, especially because flour consumption in Canada is slightly decreasing. Intermittent concerns have been raised concerning possible deleterious effects of folate supplementation, including the masking of symptoms.

Neural Tube Defects (NTD): Folic Acid and Pregnancy The

  1. g fewer fortified foods, may not have adequate dietary intake of folic acid
  2. Introduction. Neural tube defects (NTD) are one of the most common types of congenital malformations characterized by incomplete closure of the embryonic neural tube. 1 Anencephaly and spina bifida are the two most common types of NTD that affect the brain and spinal cord, respectively. 2-4 These defects occur between 21 and 28 days after conception when most women are unaware of their.
  3. (a) Relationship between folate and neural tube defects - (1) Definition. Neural tube defects are serious birth defects of the brain or spinal cord that can result in infant mortality or serious disability. The birth defects anencephaly and spina bifida are the most common forms of neural tube defects and account for about 90 percent of these defects
  4. utes or two 20
  5. Fig. 3 Decline in neural-tube defects (NTD) by the periconceptional application of folic acid in primary intervention trials or after fortification (NTD diagnosed at birth or abortion).+400 (+800), μg folic acid/d in randomised controlled trials, verum v. placebo group; fortif., before and after the mandatory fortification of cereal-grain.

Neural tube defects have been associated with both genetic factors - e.g. simple gene mutations and chromosomal abnormalities 7 - and maternal factors such as folate intake, age, ethnicity, obesity and the use of antiepileptic drugs. 8 If maternal intake of folic acid can be increased around the time of conception, the risk of the. Folic Acid for the Prevention of Neural Tube Defects: Preventive Medication [2017] WHO. World Health Organization. Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects [2015] Periconceptional folic acid supplementation to prevent neural tube defects {Related topics} Guideline Nutritional Ecogenetics: Homocysteine-Related Arteriosclerotic Vascular Disease, Neural Tube Defects, and Folic Acid. Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content National Institutes of Health. Folate, folic acid and neural tube defects. Birth defects are one of the leading causes of infant mortality worldwide and affect an estimated 1% to 3% of all births . About 276,000 babies die within 4 weeks of birth every year worldwide from congenital anomalies (7% of all neonatal deaths), which represent structural or functional anomalies (e.

A deficiency of folate itself does not cause neural tube defects. The association seen between reduced neural tube defects and folic acid supplementation is due to a gene-environment interaction such as vulnerability caused by the C677T Methylenetetrahydrofolate reductase (MTHFR) variant Neural tube defects are major birth defects in a baby's brain (anencephaly) or spine (spina bifida). But about half of all pregnancies are unplanned. Therefore, all women and teen girls who could become pregnant should consume 400 mcg of folic acid daily from supplements, fortified foods, or both, in addition to the folate they get from. Neural tube defects (NTDs) are among the most common congenital malformations. Each year in the United States, approximately 2500 infants are born with NTDs.1 Additionally, an unknown number of fetuses affected by these birth defects are aborted. The major types of NTDs, spina bifida and anencephaly, have a prevalence of approximately 5 per 1000 in the United Kingdom and 1 per 1000 in the.

Folic acid in neural tube defectThousands of babies suffer birth defects due to 'failureFolic Acid Deficiency Causes, Signs, Diagnosis, Mnemonic

Neural tube defect and folic acid

  1. Many women do not receive folic acid supplements before conception. In response, most of Canada's cereal grain products were being fortified with folic acid by January, 1998, thereby providing an additional 0·1-0·2 mg per day of dietary folate to the Canadian population. We assessed the effect of supplementation on prevalence of open neural tube defects in the province of Ontario
  2. ed in relation to the effects of folic acid (FA) supplementation. We hypothesised that FA may have a disproportionate effect that alters the sex-specific prevalence of NTDs. Setting Data from two time points, before.
  3. Detailed methods and contextual information (on current intake of folic acid from diet and other sources, effect of folic acid outside the periconceptional period, variation in benefits by risk factors, and supplementation benefits other than protection against neural tube defects) are available in the full evidence report available at https.
  4. g pregnant. Preconception patient education about the need for prophylaxis is important during medical wellness visits as many women are not aware of this.

Neural tube defects and folic acid

  1. B9), is water-soluble B vita
  2. 40. Recommendations for use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. Mortal Morb Wkly Rep 1992; 41(RR14): 1-7. 41. Society of Obstetricians and Gynecologists of Canada, Genetics Committee. Recommen-dations on use of folic acid for prevention of neural tube defects
  3. Nutritional deficiencies are preventable etiological and epigenetic factors causing congenital abnormalities, first cause of infant mortality. Folate deficiency has a well-established teratogenic effect, leading to an increasing risk of neural tube defects. This paper highlights the most recent medical literature about folate deficiency, be it maternal or paternal
  4. Folic acid is the only form of folate that has been shown to reduce the risk of neural tube defects, a serious birth defect that involves the brain and spine. There is also a synthetic version of 5-methyltetrahydrofolate; we'll call this synthetic 5-methylTHF
  5. Folic acid for pregnancy. Folic acid is a crucial nutrient during pregnancy. It helps prevent certain birth defects, and it contributes to the healthy growth of your placenta and baby. Folic acid also helps prevent a type of anemia. Most women need 600 mcg of folic acid during pregnancy (more in some cases), and you'll want to take a supplement.
  6. B9 is an essential nutrients and its chemical name is pteroyl-L-glutamic acid, and pteroyl-L-glutamate [1]. Folic acid is vital for several functions of the body as it is used to protect cells in the body
  7. The neural tubes are considered as a feature of the brain and the backbone. The top tube is connected to the brain during development, and the rest is related to the spinal cord. The neural and spina bifida tube defects here. The folic acid fetus of pregnant women was particularly susceptible to spina bifida and anencephaly

Folic acid is used for preventing and treating low blood levels of folate (folate deficiency), as well as its complications, including anemia and the inability of the bowel to absorb nutrients properly (e.g. Celiac sprue and Crohn's disease). Folic acid is also used for other conditions commonly associated with folate deficiency, including. In 1999 Berry et al conclusively found that a daily dose of 400 µg of folic acid alone resulted in a reduction in neural tube defect risk (first occurrence) similar to that reported in earlier studies, when taken at least one month before conception and for 12 weeks after conceiving Folic Acid and Neural Tube Defects. By Gerald T. Keegan, MD, FACS and Lynn Keegan, RN, PhD, HNC, FAAN. Neural tube defects (NTD) constitute an extensive spectrum of disease processes—from relatively mild manifestations to those that have a devastating impact on the individual sufferer, the extended family, and society as a whole Low knowledge levels of the connection between folic acid and the prevention of neural tube defects (Women did not know that folic acid could prevent birth defects). Pre-conceptional behaviors: the constellation of behaviors that could affect a pregnancy in a positive or negative way; specifically: multivitamin use, healthy diet (emphasizing. 10. Wald NJ. Folic acid and the prevention of neural tube defects. N Engl J Med 2004;350:101-3. 11. Wald NJ, Law MR, Morris JK, et al. Quantifying the effect of folic acid. Lancet 2001;358:2069-73. 12. National Survey of Pakistan 1990-94. Islamabad: PMRC, 1998. 13. Berry RJ, Zhu LI, Ericson DJ, et al. Prevention of neural tube defects with.

[Neural tube defects and folic acid]

  1. Folic acid is better absorbed into the body as compared to folate. What are Neural tube defects? Neural tube defects (NTD's) are birth defects of the brain, spine or spinal cord. It develops into a tube by the end of the first month of pregnancy therefore by the time most women even find out they are pregnant it has been developed already
  2. Successful neurulation leading to the closure of the neural tube requires strict control over cell death, proliferation, differentiation, and migration (Zakeri and Ahuja, 1997).Disruption of the genetic, biochemical, and morphological control of these processes is thought to be the underlying mechanism mediating neural tube defects (NTDs) (Fernandez et al., 2003)
  3. One neural tube defect is called spina bifida, which folic acid can prevent. Another defect is the condition in which a few parts of the brain and skull are absent all together. Just by reading this, you will realize how important folic acid is for the development of your baby. It is important that you take folic acid during the first trimester.

Reported maternal fever, fever severity, and average daily folic acid intake during the periconceptional period ∗ and risk for neural tube defects after excluding (1) 231 women with pre-existing diabetes, family history of neural tube defect, or periconceptional exposure to antiepileptic drugs, (2) 91 nonisolated cases, and (3) 111 cases with. A.E. Freeman Legumes contain folic acid. One important connection between folic acid and neural tube defects is that taking enough folic acid during pregnancy and before the pregnancy helps to prevent the formation of defects in a fetus.Most neural tube defects occur within the first 30 days of pregnancy, and a woman needs to ensure that she takes in enough folate or folic acid before the. Neural tube defects are among the most common birth defects, contributing to miscarriage, infant mortality, severe congenital abnormalities and serious disabilities. It is burdensome to patients, caregivers, healthcare systems and society. It could be reduced if women consume a folic acid supplement before and during the early weeks of pregnancy The history of intervention trials of periconception folic acid with multivitamin and folic acid supplementation in women has shown a recent breakthrough in the primary prevention of structural bir..

Neural Tube Defects in Relation to Use of Folic Acid

Background Taking folic acid supplements before pregnancy to reduce the risk of a neural tube defect (NTD) is especially important in countries without universal folic acid fortification. The extent of folic acid supplementation among women who had antenatal screening for Down's syndrome and NTDs at the Wolfson Institute of Preventive Medicine, London between 1999 and 2012 was assessed Neural tube defects (NTDs) are common and serious malformations that originate early in pregnancy. In the United States, approximately 4000 pregnancies each year are affected by the two most common NTDs (spina bifida and anencephaly). Neural Tube Defect Surveillance and Folic Acid Intervention—Texas-Mexico Border, 1993-1998. JAMA. 2000.

Folic Acid for the Prevention of Neural Tube Defects

  1. consume 400 mg of folic acid daily to prevent neural tube defects (NTDs). Studies have demonstrated that pericon-ceptional folic acid supplementation can prevent 50% or more of NTDs such as spina bifida and anencephaly. For women who have previously had an NTD-affected preg-nancy, the Centers for Disease Control and Preventio
  2. It's not clear why folic acid has such a profound effect on the prevention of neural tube defects. But experts do know that it's vital to the development of DNA . As a result, folic acid plays a large role in cell growth and development, as well as tissue formation
  3. or high dose of folic acid alone in the.
  4. Folic acid is a synthetic form of folate used in supplements and fortified staple foods (like wheat and maize flour) to reduce the occurrence of neural tube defects (NTDs). These include spina bifida (or cleft spine), where there is an opening in one or more of the bones (vertebrae) of the spinal column, and anencephaly where the head (cephalic.
  5. In 1998, the U.S. implemented a plan to fortify wheat-based products with folic acid, in the hopes of decreasing the incidence of spina bifida and other neural tube defects. Unfortunately, folic acid is a synthetic form of folate, and converting it to the active form is costly to the liver
  6. Neural tube defects (NTDs) are a heterogeneous group of structural birth defects that arise from a complex array of genetic and environmental factors and adversely affect the structure and function of the brain and spinal cord [].The United States of America (USA) was the first country to mandate a national folic acid food fortification program to prevent NTDs including spina bifida

Folic acid is a water-soluble B-vitamin that helps build healthy cells, but it does not stay in the body long. It is important that women take folic acid every day to help reduce the risk of neural tube defects Neural tube defects (NTDs) are the second most common group of serious birth defects. Although folic acid has been shown to reduce effectively the risk of NTDs and measures have been taken to increase the awareness, knowledge, and consumption of folic acid, the full potential of folic acid to reduce the risk of NTDs has not been realized in most countries A 2009 study concluded that folic acid supplements taken by pregnant women weren't enough to prevent some neural tube defects. Public health experts have debated whether to increase the current. Taking folic acid around the time of conception and for the first 12 weeks reduces the risk of neural tube birth defects by 72% to 100%. There is some evidence that folic acid supplementation during pregnancy also reduces the risk of miscarriage, autism development, and language delay Folic acid is a vitamin that every cell in your body needs for healthy growth and development. If you take it before pregnancy and during early pregnancy, it can help protect your baby from birth defects of the brain and spine called neural tube defects. The neural tube is the part of a developing baby that becomes the brain and spinal cord

Fn1 pptSpina bifida

Neural tube defect surveillance and folic acid

Studies show that women of childbearing age who add folic acid to their diets can significantly reduce the risk of having a child with a neural tube defect. Therefore, it is recommended that all women of childbearing age take a daily vitamin supplement with 400 micrograms of folic acid before and during early pregnancy The prevalence of neural tube defect was 3.5 per 1000 among women who never used multivitamins before or after conception or who used multivitamins before conception only. The prevalence of neural tube defects for women who used folic acid-containing multivitamins during the first 6 weeks of pregnancy was substantially lower—0.9 per 1000. FOLIC ACID: The prevention of neural tube defects. Also called vitamin M, vitamin B9, folacin or pteroyl-L-glutamic acid. Folic acid is a water-soluble vitamin of the B Group and it is the only active form of folate absorbed by the body.It is synthetically produced,because it is not naturally found in food,contrary to folate

Folic Acid: Birth Defects COUNT Questions and Answers - CD

Folic Acid, Calcium, Iodine, and Iron. Folic acid. If getting pregnant is a possibility for you, you should take folic acid. It can prevent birth defects that affect the baby's brain and spinal. Fewer than 40% of U.S. women are taking folic acid supplements periconceptionally at a time when the risk of neural tube defects (NTDs) can be reduced by supplementation. A better understanding of the vitamin-taking habits of childbearing-age women and effective methods for improving periconceptional supplement use are needed Decreased risk of congenital deformities. It is essential to consume enough folic acid during pregnancy to help protect against miscarriage and neural tube defects in the fetus

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